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Atlanta: U.S. Department of Health and Human Services, Public Health Service. C v CADMIUM FOREWORD This toxicological profile is prepared in accordance with guidelines* developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). Case studies in environmental medicine: Cadmium toxicity. Agency for Toxic Substances and Disease Registry (ATSDR). The 2015 chronic HRL for cadmium (0.5 µg/L) is … 1993. The kidney is the critical target and shows the earliest sign of cadmium toxicity. The original guidelines were published in the Federal Register on April 17, 1987. The 2015 acute health Risk Limit (HRL) for cadmium (5 µg/L) is slightly higher than the 1993 HRL of 4 µg/L. Agency for Toxic Substances and Disease Registry (ATSDR). For more information, call the ATSDR Information Center at 1-800-232-4636. It is usually present in the environment as a mineral combined with other elements like oxygen, chlorine, or sulfur. The original guidelines were published in the Federal Register on April 17, 1987. The target organ for cadmium toxicity via oral exposure is the kidney (Goyer, 1991). Cadmium is a naturally occurring metal. The Agency for Toxic Substances & Disease Registry (ATSDR) offers a self-instructional module on “Taking an Exposure History” which provides an exposure history form in Appendix 1. Medical History: A medical history may help identify possible symptoms that could be associated with cadmium poisoning. Therefore, toxicity of cadmium generally results from chronic exposure. There is limited evidence from epidemiologic studies for cadmium-related respiratory tract cancer (ATSDR, 1989). For inhalation exposure, both the lungs and kidneys are target organs for cadmium-induced toxicity (ATSDR, 1989; Goyer, 1991). Toxicological Profile for Lead. Toxicological Profile for Cadmium. (1) Agency for Toxic Substances and Disease Registry (ATSDR) Cadmium that enters the body tends to accumulate in the kidney and liver. Toxicological profile for cadmium. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Services. Cadmium is an accumulative toxicant with a long biological half‐life that has been estimated to be 10 to 33 years in humans, which results in increased body burden over time (Clemens et al., 2013; EFSA, 2009). Each profile will be revised and republished as necessary. Cadmium in the kidneys can have a half-life of several decades. 1993. Agency for Toxic Substances and Disease Registry Division of Toxicology and Environmental Medicine ToxFAQs TM September 2008 This fact sheet answers the most frequently asked health questions (FAQs) about cadmium. The reasons it is higher are: 1) use of more recent toxicity information; and 2) rouding to one n significant digit. Tweet this: “ATSDR’s Toxic Substances Portal is an easy reference for researchers & individuals to find information about toxic chemicals, understand how they can affect health, and learn how to prevent exposure.Visit https://bit.ly/2JOOIif #CDCEHblog via @CDCEnvironment” This toxicological profile is prepared in accordance with guidelines * developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). This fact sheet is one in a series Absorbed cadmium accumulates mainly in the kidney and liver, with an estimated half-life of 6–38 years, and 4–19 years, respectively, and no direct metabolism is known (ATSDR, 2012). Either short-term or long-term exposure to cadmium can cause serious health problems. 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